This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. Promotes the production of saliva, gastric juices and bile which aid in digestion. Planta Medica 1978;33:275. Fitoterapia 2000;71:S95-100. Gentian root contains triterpenoids, xanthones, and different constituents. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Preparations of gentian roots can therefore help with complaints such as appetite control and digestion, mitigate sugar cravings, bloating, flatulence, biliary disorders, and to improve overall skin health. Suzuki, O., Katsumata, Y., and Oya, M. Inhibition of monoamine oxidase by isogentisin and its 3-O-glucoside. View abstract. Gentian root is not related to the gentian violet dye (methylrosaniline chloride). Biochem Pharmacol 1978;27(16):2075-2078. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. The highly toxic white hellebore (Veratrum album) can be mistaken for gentian and has caused accidental poisoning when used in homemade preparations. It is used as a liver tonic and for the making of Angostura bitters. Select one or more newsletters to continue. If you plan to make your own gentian preparation, be sure you identify gentian correctly. Phytochemistry 1988;27:3696-3699. (detailed description of each of the ratings). Sticher, O. and Meier, B. Quantitative determination of the bitter principles in the roots of Gentiana lutea and Gentiana purpurea with HPLC [high-pressure liquid chromatography]. There are no clinical studies to substantiate this dosage recommendation.WHO 1999, Mutagenic activity has been demonstrated in assays, and G. lutea has been traditionally used as an emmenagogue. GENTIANA LUTEA ROOT EXTRACT is classified as : Skin conditioning; CAS Number: 72968-42-4 / 97676-22-7 EINECS/ELINCS No: 277-139-0 / - COSING REF No: 56165 Chem/IUPAC Name: Gentiana Lutea Root Extract is an extract of the rhizomes and roots of the Gentian, Gentiana lutea, Gentianaceae 7. Acute veratrum alkaloid poisoning has been reported due to accidental contamination of gentian preparations by veratrum. Scientific Name(s): Gentiana acaulis L., Gentiana lutea L., Gentiana scabra Bunge.Common Name(s): Bitter root, Bitterwort, Felwort, Gall weed, Gentian, Gentiana, Radix Gentianae Lutea. Planta Medica 1980;38:344-350. Ethanol extracts of the roots and rhizomes of G. lutea have increased gastric secretions in rats and sheep.WHO 1999, In 2 uncontrolled clinical studies, stimulation of gastric secretions was increased and GI symptoms (eg, abdominal pain, constipation, dyspepsia, heartburn) were reduced.WHO 1999, Gentian extracts have hydroxy radical scavenging activityCalliste 2001, Kusar 2006 and exert a protective effect against ketoconazole-induced testicular damage in rats, assumed to be due to antioxidant effects.Amin 2008 Gentiopicroside and the essential oil of G. lutea relax smooth muscle in isolated animal trachea and ileum.Rojas 2000, WHO 1999 Gentian extracts prolong swimming endurance in mice.Öztürk 2002, The pharmacokinetics and tissue distribution of gentiopicroside after oral and parenteral administration have been studied in mice. The use of Gentian root extract in the U.S. has an interesting history; it was considered a medicinal herb and was used as an ingredient of a patent medicine invented in 1876 by a physician in Maine. Chem Pharm Bull (Tokyo) 2003;51:89-91. Borgia, M., Sepe, N., Borgia, R., and Ori-Bellometti, M. Pharmacological activity of a herb extract: a controlled clinical study. The plant has been used externally to treat wounds and internally to treat sore throat, arthritic inflammation, and jaundice. description. Citova, I., Ganzera, M., Stuppner, H., and Solich, P. Determination of gentisin, isogentisin, and amarogentin in Gentiana lutea L. by capillary electrophoresis. J Pharm Biomed.Anal 9-3-2007;44(5):1113-1117. Phytochemistry 2004;65:2255-60. Gentian root consists of xanthones, triterpenoids and other constituents. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. The speed of drying of the roots affects their properties as medicinal bitters. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Gentian Root Extract by Carrubba offers anti-inflammatory and astringent benefits. View abstract. View abstract. View abstract. Phytomedicine 1994;1:177-81. This information is not specific medical advice and does not replace information you receive from your health care provider. The following doses have been studied in scientific research: Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings). View abstract. The roots and rhizomes of G. lutea are used medicinally.Meyer 1934, PLANTS 2010, WHO 1999, G. acaulis is a smaller herb with a basal rosette of lance-shaped leaves and generally grows to 10 cm in height. This information relates to an herbal, vitamin, mineral or other dietary supplement. Radix Gentianae Lutea is contraindicated in GI or duodenal ulcer. The extracts are used in a variety of foods, cosmetics, and some antismoking products. Stemless gentian usually is consumed as a tea or alcoholic extract, such as Angostura bitters. Ann.Med.Interne (Paris) 1985;136(2):125-128. 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